Bioliance lab results: LEO
Bioliance website: BIOLIANCE

Time lapse

The “time lapse” system is a camera which regularly takes pictures of the embryos throughout their culture in the laboratory.

It is a genuine “movie” of the embryo development that is going to be made.


First developed for research, this technology has several advantages in current practice for ART care. These advantages can be divided into two categories:

  1. For the choice of embryos at the time of the transfer
    The shooting of this movie about embryo development gives a complete overview of the embryo and gives the opportunity to really compare the embryos between themselves in a more objective way (particularly in terms of developing speed). In current practice, embryos are checked between 3 and 6 times and at standard moments (fertilisation, 1st division, D2, D3, D5). There is limited or no information at all regarding what goes on outside of these observation stages.Moreover, the studies carried out with the time lapse system allowed to collect information on the embryo evolution and highlighted new standards for embryo selection.
  2. For culture conditions
    The aim of in vitro embryo culture is to recreate in the best way in vivo conditions particularly regarding temperature and hypoxia (limited oxygen level).
    Beyond the technical characteristics of the several containers, the access to culture dishes is based on the principle of a manual opening and closing. Thus, to be able to follow the evolution of embryos in view of a transfer (as described above), the doors are at least opened 6 times.
    The time lapse principle is to be able to follow the embryo evolution both more precisely but also in a non harmful way by keeping strict constant conditions throughout culture.


Presentation Video :

Time Lapse experience at the PMAtlantique Center: